Christine Wanke, MD

Positions:

 

Director of the Nutrition and Infection Unit
Associate Chair and Professor, Department of Public Health and Community Medicine
Professor, Department of Medicine, Tufts University School of Medicine
Professor, Sackler School of Biomedical Science
Professor, Friedman School of Nutrition Science and Policy

Contact:

 

Tufts University School of Medicine
150 Harrison Avenue, Jaharis 2
Boston, MA 02111

Phone: 617.636.3811
Fax: 617.636.3810
Email: christine.wanke@tufts.edu

Education

MD, University of Wisconsin School of Medicine

Research Focus:

My research interests are in the intersection of nutritional compromise and infectious diseases, particularly diarrheal disease and growth faltering in children in the resource limited world and in patients infected with HIV, whether in the US or in the resource limited world. In studies of growth faltering our interests are in maternal as well as infant factors and we are interested in pathogenesis as well as the development of potential interventions. A particular interest is in the role of altered intestinal microbiota, bacterial translocation, and immune activation. In terms of HIV and nutrition, we view the intersection of HIV and nutrition broadly, to include behavioral, psychological, socio-economic factors that contribute to the relationship between nutrition and HIV. Our interests include the prevalence of food security, the impact of food security on entry and  retention in care, adherence to ART, the impact of food security and nutrition on progression of HIV infection and on complications of HIV infections, including cardiovascular risk and other infections, such as tuberculosis or hepatitis. We have an interest in intestinal microbiota in HIV, as well as intestinal function and immune activation/inflammation in HIV, The approach our research employs attempts to include potential translational elements, such as cost effectiveness of interventions in our studies. Trainees are involved in all aspects of our research and include US trained post doctoral fellows as well as international trainees.

Select Publications:

 

  1. Mangili A, Polak JF, Quach LA, Gerrior J, Wanke CA.  Markers of Altherosclerosis and Inflammation and Mortality in Patients with HIV Infection.  Atherosclerosis, 2011 Feb; 214(2):468-473; Epub 2010 Nov 17.  PMCID:  PMC3034311.
  2. Padmapriyadarisini C, Ramesh KS, Terrin N, Narendran G, Menon PA, Ramachandran G, Subramanyan S, Venkatesan P, Wanke C, Swaminathan S.  Dyslipidemia among HIV-Infected Patients with Tuberculosis Taking Once Daily Nonnucleoside Reverse-Transcriptase Inhibitor-Based Antiretroviral Therapy in India.  Clinical Infectious Diseases 2011 (Feb); 52(4):540-546. Epub 2011 Jan 20. PMCID:  PMC3060904.
  3. McMahon JH, Jordan MR, Kelley K, Bertagnolio S, Hong SY, Wanke CA, Lewin SR, Elliott JH.  Pharmacy Adherence Measures to Assess Adherence to Antiretroviral Therapy:  Review of the Literature and Implicatons for Treatment Monitoring.  Clinical Infectious Dieseases 2011 Feb; 52(4):493-506.  Epub 2011 Jan 18.  PMCID:  PMC3060901.
  4. Falcone L, Mangili A, Skinner S, Ahsan A, Polak J, Wanke CA.  Framingham risk score and early markers of atherosclerosis in a cohort of adults infected with HIV. Antiretroviral Therapy Journal 2011; 16(1):1-8.
  5. Tang AM, Bhatnagar T, Ramachandran R, Dong K, Skinner S, Kumar MS, Wanke CA. Malnutrition in a population of HIV-positive and HIV-negative drug users living in Chennai, South India.  Drug Alcohol Depend. 2011 Mar 18. [Epub ahead of print] PMCID:  PMC3130882.
  6. Sudarsanam TD, John J, Kang G, Mahendri V, Gerrior J, Franciosa M, Gopal S, John KR, Wanke CA, Muliyil J. Pilot randomized trial of nutritional supplementation in patients with tuberculosis and HIV-tuberculosis coinfection receiving directly observed short-course chemotherapy for tuberculosis.  Trop Med Int Health. 2011 Mar 21. doi: 10.1111/j.1365-3156.2011.02761.x.  Pages 699-706.  [Epub ahead of print]  PMCID:  NA
  7. Yarasheski KE, Scherzer R, Kotler DP, Dobs AS, Tien PC, Lewis CE, Kronmal RA, Heymsfield SB, Bacchetti P, Grunfeld C; Study of Fat Redistribution and Metabolic Change in HIV Infection (FRAM – Wanke C included).  Age-related skeletal muscle decline is similar in HIV-infected and uninfected individuals. J Gerontol A Biol Sci Med Sci. 2011 Mar;66(3):332-40. Epub 2011 Feb PMCID: PMC3041474   [Available on 2012/3/1]
  8. McMahon JH, Wanke CA, Elliott JH, Skinner S, Tang AM.   Repeated assessments of food security predict CD4 change in the setting of antiretroviral therapy.    J Acquir Immune Defic Syndr. 2011 Sep; 58(1):60-63.  Epub ahead of print.   PMCID:  PMC3159819.
  9. Tang AM, Sheehan HB, Jordan MR, Duong DV, Terrin N, Dong K, Lien TT, Trung NV, Wanke CA, Hien ND.  Predictors of weight change in male HIV-Positive injection drug users initiating antiretroviral therapy in Hanoi, Vietnam.  AIDS Res Treatment 2011; 890308.  EPub 2011 July 6.  PMID: 21776380.   PMCID:  PMC3137978.
  10. Scherzer R, Heymsfield SB, Lee D, Powderly WG, Tien PC, Bacchetti P, Shlipak MG, Grunfeld C, Study of Fat Redistribution and Metabolic Change in HIV Infection (FRAM).  Decreased limb muscle and increased central adiposity are associated with 5-year all-cause mortality in HIV infection.  AIDS 2011 July 27; 25(211):1405-1414.  PMID: 21572308 [PubMed – in process.]
  11. Mangili A, Gerrior J, Sheehan HB, Wanke CA.  HIV infection and progression of carotid and coronary atherosclerosis:  The CARE Study.  JAIDS 2011 July 22 {epub ahead of print.  PMID:  21792061  [Pub Med – as supplied by publisher.]
  12. McMahon J, Wanke C, Terrin N, Skinner S, Knox T.  Poverty, Hunger, Education, and Residentail Status Impact Survival in HIV.  AIDS Behavior 2011 October; 15(7):1503-1511.  PMCID: PMC3010417
  13. Raiten DJ, Mulligan K, Papathakis P, Wanke C.  Executive Summary: Nutritional Care of HIV Infected Adolescents and Adults including Pregnant Women:  What Do We Know, What Can We Do, and Where Do We Go From Here?  AJCN 2011; 94:6(S)1667-1676.
  14. Rogers B, Webb P, Wanke C, Sadeu K, Masterson AR, Bagriansky J, Schussman N, Narayan A, Tilahun J.  Selection and Usage of US Title 1I Food Aid Products in Programming Contex.  Food and Nutrition Bulletin 2011; Volume 32, # 3(S):152-165.
  15. Hong S, Taur Y, Jordan MR, Wanke C.  Antimicrobial Prescribing in the USA for Adult Acute Pharyngitis in Relation to Treatment Guidelines.  Jnl of Clinical Practice 2011; 17:1176-1183.
  16. Lake JE, McComsey GA, Hulgan TM, Wanke CA, Mangili A, Walmsley SL, McCreath HE, and Currier JS.  A Randomized Trial of Raltegravir Replacement for Protease Inhibitor or Non-Nucleoside Reverse Transcriptase Inhibitor in HIV-Infected Women with Lipohypertrophy.  AIDS Patient Care and STDS 2012; 26(9):1-9.  PMCID:  PMC3426192.
  17. Hong SY, Hendricks, KM, Wanke C, Omosa G. Patta S, Mwero B, Mjombe I, Queenan J, Mwamburi, M. Development of a nutrient dense food supplement for HIV infected women in rural Kenya using qualitative and quantitative research methods. Public Health Nutrition. 2012; 114: 1-9.
  18. Hong SY, Thompson D, Wanke C, Omosa G, Jordan M, Tang A, Patta S, Mwero B, Mjomba I, Mwamburi M. Knowledge of HIV transmissionand associate factors among HIV-positive and HIV-negative patients in rural Kenya. AIDS & Clinical Research. 2012; 3:
  19. Heffernan K, Wanke CA, Dong K, Warner PJ, Anskat PE, Karas RH, Kuvin JT. Racial differences in central hemodynamic burden in men with HIV;  preliminary findings.  Ethnicity and Disease 2012.In Press.