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Tufts University School of Medicine

Athan Kuliopulos

Professor of Medicine
Programs: Cell, Molecular & Developmental Biology, Genetics
Laboratory: 75 Kneeland, 10th Floor

Athan Kuliopulos

Professor of Medicine
Programs: Cell, Molecular & Developmental Biology, Genetics
Laboratory: 75 Kneeland, 10th Floor

Phone 617-636-8482
Lab phone: 617-636-8486
Office: 75 Kneeland, 10th Floor
Campus: Boston

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Education

  • BS, Biology, Rensselaer Polytechnic Institute
  • MD, PhD, Biochemistry, Johns Hopkins Medical School
  • Postdoctoral Training, Harvard Medical School

Research synopsis

Protease-activated receptors (PARs) are a unique class of G protein-coupled receptors that play critical roles in vascular biology, inflammation and fibrosis. The PARs are cleaved by thrombin, MMP-1 and other proteases to expose a new N-terminus that binds to the body of the receptor in an unusual intramolecular mode. A major interest of our research group is to study the molecular mechanism of protease activation of the PARs and translational relevance in cardiovascular and fibrotic-inflammatory diseases.