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Tufts University School of Medicine

Christine Wanke

Professor Emerita of Medicine
Department: Public Health & Community Medicine
Programs: Clinical & Translational Science, Public Health

Christine Wanke

Professor Emerita of Medicine
Department: Public Health & Community Medicine
Programs: Clinical & Translational Science, Public Health

Phone 617-636-3811
Office: Jaharis 268
Campus: Boston

Biography

My research interests are in the intersection of nutritional compromise and infectious diseases, particularly diarrheal disease and growth faltering in children in the resource limited world and in patients infected with HIV, whether in the US or in the resource limited world. In studies of growth faltering our interests are in maternal as well as infant factors and we are interested in pathogenesis as well as the development of potential interventions. A particular interest is in the role of altered intestinal microbiota, bacterial translocation, and immune activation. In terms of HIV and nutrition, we view the intersection of HIV and nutrition broadly, to include behavioral, psychological, socio-economic factors that contribute to the relationship between nutrition and HIV. Our interests include the prevalence of food security, the impact of food security on entry and  retention in care, adherence to ART, the impact of food security and nutrition on progression of HIV infection and on complications of HIV infections, including cardiovascular risk and other infections, such as tuberculosis or hepatitis. We have an interest in intestinal microbiota in HIV, as well as intestinal function and immune activation/inflammation in HIV, The approach our research employs attempts to include potential translational elements, such as cost effectiveness of interventions in our studies. Trainees are involved in all aspects of our research and include US trained post doctoral fellows as well as international trainees.

Education

  • BA, South Asian Studies, University of Wisconsin, Madison
  • MD, University of Wisconsin School of Medicine

Research interests

Nutrition and Infectious Diseases

Research synopsis

I have two primary research interests, the first is clinical research in HIV infected individuals with an emphasis on the nutritional and metabolic complications of HIV and its therapies in both US and resource limited environments. This includes the risk for cardiovascular disease in patients infected with HIV. In addition I have a research interest in persistent diarrheal disease, particularly in children in the developing world and in adults infected with HIV. This includes the pathogens that contribute to persistent diarrheal disease, the nutritional status of individuals with persistent diarrheal disease and interventions for these persistent diarrheal illnesses.

Publications

  1. Mangili A, Polak JF, Quach LA, Gerrior J, Wanke CA. Markers of Atherosclerosis and Inflammation and Mortality in Patients with HIV Infection. Atherosclerosis, 2011 Feb; 214(2):468-473; Epub 2010 Nov 17. PMCID: PMC3034311.
  2. Padmapriyadarisini C, Ramesh KS, Terrin N, Narendran G, Menon PA, Ramachandran G, Subramanyan S, Venkatesan P, Wanke C, Swaminathan S. Dyslipidemia among HIV-Infected Patients with Tuberculosis Taking Once Daily Nonnucleoside Reverse-Transcriptase Inhibitor-Based Antiretroviral Therapy in India. Clinical Infectious Diseases 2011 (Feb); 52(4):540-546. Epub 2011 Jan 20. PMCID: PMC3060904.
  3. McMahon JH, Jordan MR, Kelley K, Bertagnolio S, Hong SY, Wanke CA, Lewin SR, Elliott JH. Pharmacy Adherence Measures to Assess Adherence to Antiretroviral Therapy: Review of the Literature and Implications for Treatment Monitoring. Clinical Infectious Diseases 2011 Feb; 52(4):493-506. Epub 2011 Jan 18. PMCID: PMC3060901.
  4. Falcone L, Mangili A, Skinner S, Ahsan A, Polak J, Wanke CA. Framingham risk score and early markers of atherosclerosis in a cohort of adults infected with HIV. Antiretroviral Therapy Journal 2011; 16(1):1-8.
  5. Tang AM, Bhatnagar T, Ramachandran R, Dong K, Skinner S, Kumar MS, Wanke CA. Malnutrition in a population of HIV-positive and HIV-negative drug users living in Chennai, South India. Drug Alcohol Depend. 2011 Mar 18. [Epub ahead of print] PMCID: PMC3130882.
  6. Sudarsanam TD, John J, Kang G, Mahendri V, Gerrior J, Franciosa M, Gopal S, John KR, Wanke CA, Muliyil J. Pilot randomized trial of nutritional supplementation in patients with tuberculosis and HIV-tuberculosis coinfection receiving directly observed short-course chemotherapy for tuberculosis. Trop Med Int Health. 2011 Mar 21. doi: 10.1111/j.1365-3156.2011.02761.x. Pages 699-706. [Epub ahead of print] PMCID: NA