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Tufts University School of Medicine

Daniel Jay

Professor of Developmental, Molecular & Chemical Biology
Department: Developmental Molecular and Chemical Biology
Programs: Cell, Molecular & Developmental Biology, Neuroscience
Laboratory: M&V 709

Daniel Jay

Professor of Developmental, Molecular & Chemical Biology
Department: Developmental Molecular and Chemical Biology
Programs: Cell, Molecular & Developmental Biology, Neuroscience
Laboratory: M&V 709

Phone 617-636-6714
Lab phone: 617-636-2957
Office: M&V 714
Campus: Boston

Links

Education

  • BS, Biochemistry & Chemistry, University of Toronto
  • PhD, Biochemistry & Molecular Biology, Harvard University
  • Postdoctoral Training, Harvard University

Research synopsis

We developed Chromophore-Assisted Laser Inactivation (CALI) to inactivate specific proteins in living cells at precise times and location. We used CALI with antibody libraries in a high throughput and automated fashion to discover new proteins that act in cancer cell invasiveness identified an extracellular form of Heat Shock Protein 90 (Hsp90) that acts to activate pro-invasive proteins in the tumor microenvironment to increase invasion, the first step in metastasis. We are currently pursuing how this activation occurs and whether inhibition of extracellular Hsp90 could be a novel treatment to reduce metastasis of breast cancer.