Programs: Cell, Molecular & Developmental Biology, Neuroscience
- BS, Biochemistry & Chemistry, University of Toronto
- PhD, Biochemistry & Molecular Biology, Harvard University
- Postdoctoral Training, Harvard University
We developed Chromophore-Assisted Laser Inactivation (CALI) to inactivate specific proteins in living cells at precise times and location. We used CALI with antibody libraries in a high throughput and automated fashion to discover new proteins that act in cancer cell invasiveness identified an extracellular form of Heat Shock Protein 90 (Hsp90) that acts to activate pro-invasive proteins in the tumor microenvironment to increase invasion, the first step in metastasis. We are currently pursuing how this activation occurs and whether inhibition of extracellular Hsp90 could be a novel treatment to reduce metastasis of breast cancer.