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Tufts University School of Medicine

Giuseppina Tesco

Professor of Neuroscience
Department: Neuroscience
Programs: Neuroscience
Laboratory: Arnold 305

Giuseppina Tesco

Professor of Neuroscience
Department: Neuroscience
Programs: Neuroscience
Laboratory: Arnold 305

Phone 617-636-4050
Lab phone: 617-636-0938
Office: Stearns 328A
Campus: Boston

Education

  • MD, University of Florence
  • PhD, Neuroscience, University of Florence
  • Postdoctoral Training, Harvard Medical School

Research synopsis

Alzheimer's disease (AD) is a devastating neurodegenerative disorder that results in loss of memory and cognitive function, eventually leading to dementia. A key neuropathological event in AD is the cerebral accumulation of senile plaques formed by aggregates of amyloid-beta-peptides derived from serial proteolysis of the amyloid precursor protein by BACE1 and gamma-secretase. Our studies have revealed a novel mechanism of BACE1 regulation mediated by the BACE1-interacting molecule GGA3. We are probing the molecular mechanisms with a long range goal of understanding AD pathogenesis.