Programs: Biomedical Sciences
Work in the lab is focused on understanding the molecular mechanisms that control cellular growth and differentiation during development or disease. Using the vasculature as a model system for in vitro and in vivo studies, we implement morphologic, biochemical and molecular genetic approaches. Experimental results should yield important new insights into the molecular and cellular regulators that control cell migration and division, angiogenesis and hypertension or wound healing.
- BA, Biology, SUNY, Buffalo
- PhD, Cell & Molecular Biology, Tulane University
Sheets AR, Demidova-Rice TN, Shi L, Ronfard V, Grover KV, Herman IM. 2016. Identification and characterization of novel matrix-derived bioactive peptides: A role for collagenase from Santyl® ointment in post-debridement wound healing? PLoS One 11: e0159598.
Sheets AR, Massey CJ, Cronk SM, Iafrati MD, Herman IM. 2016. Matrix- and plasma-derived peptides promote tissue-specific injury responses and wound healing in diabetic swine. J Transl Med. 14: 197.
Sheets AR, Durham JT, Herman IM. 2016. Quantitative imaging-based examination of pericytes controlling endothelial growth dynamics and angiogenesis. Methods Mol Biol. 1430: 221-229.
Durham JT, Dulmovits BM, Cronk SM, Sheets AR, Herman IM. 2015. Pericyte chemomechanics and the angiogenic switch: insights into the pathogenesis of proliferative diabetic retinopathy? Invest Ophthalmol Vis Sci. 56: 3441-3459.
Cronk SM, Kelly-Goss MR, Ray HC, Mendel TA, Hoehn KL, Bruce AC, Dey BK, Guendel AM, Tavakol DN, Herman IM, Peirce SM, Yates PA 2015. Adipose-derived stem cells from diabetic mice show impaired vascular stabilization in a murine model of diabetic retinopathy. Stem Cells Transl Med. 4: 459-467.
Durham JT, Surks HK, Dulmovits BM, Herman IM. 2014. Pericyte contractility controls endothelial cell cycle progression and sprouting: Insights into angiogenic switch mechanics. Am J Physiol Cell Physiol. 307: C878-C892.