My laboratory uses NMR (nuclear magnetic resonance) spectroscopy and other biophysical methods to determine high-resolution models for proteins, to quantify molecular interactions, and to measure metabolite levels in tissues and cells. Molecular agents are designed from these 3-dimensional structures to help develop inhibitor s to major human diseases such as cervical cancer and thrombosis. More specifically, we are examining proteins of the human papillomavirus (HPV), which is the causal agent for both the common wart and cervical cancer. We also are studying the Eps15-homology (EH) domain from proteins that link intracellular molecular trafficking to signal transduction with specific applications to epithelial cancers such as squamous cell carcinoma.