Programs: Immunology, Molecular Microbiology
- BA, Biochemistry, Swarthmore College
- PhD, Cellular & Molecular Biology, University of Wisconsin, Madison
- Postdoctoral Training, Stanford University
Yersinia pseudotuberculosis is an enteric pathogen that causes gastroenteritis, mesentric adenitis and occasionally spreads systemically. In order for the bacteria to cause disease and be transmitted to another host, they must survive in the gastrointestinal tract. We study the bacterial genes necessary for survival within the small intestine. We have found that one or more of the Yops, proteins that are secreted by Yersinia and translocated into host cells where they alter the function of mammalian cells, are required for Yersinia to grow in the small intestine. We are determining which Yops are required and the cells they target in the small intestine.