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Tufts University School of Medicine

John Coffin

American Cancer Society Professor of Molecular Biology
Department: Molecular Biology and Microbiology
Programs: Genetics, Immunology, Molecular Microbiology, Biomedical Sciences
Laboratory: Jaharis 401C

John Coffin

American Cancer Society Professor of Molecular Biology
Department: Molecular Biology and Microbiology
Programs: Genetics, Immunology, Molecular Microbiology, Biomedical Sciences
Laboratory: Jaharis 401C

Phone 617-636-6528
Lab phone: 617-636-6526
Office: Jaharis 409
Campus: Boston

Links

Biography

​Our research interests revolve around obtaining a better understanding of the interaction of retroviruses with their host cells and organisms. We use simple retroviruses (avian and murine viruses) to elucidate the nature of the retrovirus-receptor interaction; the mechanism and specificity of integration of viral DNA into host DNA; control of viral gene expression; mechanism of retroviral genetic variation; and evolution of the host-virus relationship, as revealed by the fossil record provided by endogenous proviruses found in the normal DNA of all vertebrates and many other species.

Education

  • BA, Biology, Wesleyan University
  • PhD, Molecular Biology, University of Wisconsin, Madison
  • Postdoctoral Training, Institut für Molekularbiologie, University of Zürich

Research synopsis

Our research interests revolve around obtaining a better understanding of the interaction of retroviruses with their host cells and organisms. We use simple retroviruses (avian and murine viruses) as well as HIV to elucidate the nature of the retrovirus-receptor interaction; control of viral gene expression; mechanism of retroviral genetic variation; and evolution of the host-virus relationship, as revealed by the fossil record provided by endogenous proviruses found in the normal DNA of all vertebrates and many other species.

Publications

Van Zyl GU, Katusiime MG, Wiegand A, McManus WR, Bale MJ, Halvas EK, Luke B, Boltz VF, Spindler J, Laughton B, Engelbrecht S, Coffin JM, Cotton MF, Shao W, Mellors JW, Kearney MF. 2017. No evidence of HIV replication in children on antiretroviral therapy. J Clin Invest.

Montesion M, Bhardwaj N, Williams ZH, Kuperwasser C, Coffin JM. 2017. Mechanisms of HERV-K (HML-2) transcription during human mammary epithelial cell transformation. J Virol. Epub ahead of print.

Wiegand A, Spindler J, Hong FF, Shao W, Cyktor JC, Cillo AR, Halvas EK, Coffin JM, Mellors JW, Kearney MF 2017. Proc Natl Acad Sci USA Epub ahead of print.

Gay CL, Bosch RJ, Ritz J, Hataye JM, Aga E, Tressler RL, Mason SW, Hwang CK, Grasela DM, Ray N, Cyktor JC, Coffin JM, Acosta EP, Koup RA, Mellors JW, Eron JJ; AIDS Clinical Trials 5326 Study Team. 2017. Clinical trial of the anti-PD-L1 antibody BMS-936559 in HIV-1 infected participants on suppressive antiretroviral therapy. J Infect Dis. Epub ahead of print.

Wildschutte JH, Coffin JM. 2017. Pushing the envelope. Elife 6. pii: e26397.

Bui JK, Sobolewski MD, Keele BF, Spindler J, Musick A, Wiegand A, Luke BT, Shao W, Hughes SH, Coffin JM, Kearney MF, Mellors JW. 2017. Proviruses with identical sequences comprise a large fraction of the replication-competent HIV reservoir. PLoS Pathog. 13: e1006283.