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Tufts University School of Medicine

Joshua Kritzer

Associate Professor of Chemistry
Programs: Cell, Molecular & Developmental Biology, Molecular Microbiology
Laboratory: Pearson 205; Michael 103

Joshua Kritzer

Associate Professor of Chemistry
Programs: Cell, Molecular & Developmental Biology, Molecular Microbiology
Laboratory: Pearson 205; Michael 103

Phone 617-627-0451
Lab phone: 617-627-3881
Office: Pearson 305B
Campus: Medford

Links

Education

  • BE, Chemical Engineering, The Cooper Union
  • PhD, Biophysical Chemistry, Yale University
  • Postdoctoral Training, Whitehead Institute, MIT

Research synopsis

The Kritzer lab uses peptides and peptidomimetics (peptide-like synthetic molecules) to inhibit disease-associated proteins that would be difficult or impossible to target using traditional approaches. These molecules are an exciting and rapidly expanding area of drug development because they can target protein surfaces in ways small molecules rarely do. We discover, develop and apply new classes of peptides using cross-disciplinary approaches including genetics, cell biology, organic synthesis, structural biology and biophysical chemistry. Our molecules alter critical pathways in pathogens and host cells, including virulence factors, phosphatase signaling, autophagy, and vesicle trafficking.