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Tufts University School of Medicine

Rachel Buchsbaum

Jane F Desforges MD Chair of Hematology & Oncology
Programs: Genetics
Laboratory: 75 Kneeland, 12th Floor

Rachel Buchsbaum

Jane F Desforges MD Chair of Hematology & Oncology
Programs: Genetics
Laboratory: 75 Kneeland, 12th Floor

Phone 617-636-5147
Lab phone: 617-636-9554
Office: 75 Kneeland, 12th Floor
Campus: Boston

Links

Education

  • AB, Chemistry & Physics, Harvard University
  • MD, Cornell University Medical College
  • Postdoctoral Training, Tufts University School of Medicine

Research synopsis

My laboratory focuses on studying signal transduction pathways underlying cancer cell growth and metastasis. In particular, we are interested in pathways involving the Rac protein, a member of the Ras superfamily that is a central player in multiple signaling pathways affecting malignant cell behavior. We have found that Rac signaling can be directed through a network of distinct pathways, involving cell survival and apoptosis, cell cycling and growth, and migration and invasion, by a major regulator protein, Tiam1. A major interest is the regulation of this Tiam1/Rac signaling network in normal and malignant cells. We are also exploring the role of this network in governing interactions between tumor cells and their microenvironment.