- AB, Chemistry & Physics, Harvard University
- MD, Cornell University Medical College
- Postdoctoral Training, Tufts University School of Medicine
My laboratory focuses on studying signal transduction pathways underlying cancer cell growth and metastasis. In particular, we are interested in pathways involving the Rac protein, a member of the Ras superfamily that is a central player in multiple signaling pathways affecting malignant cell behavior. We have found that Rac signaling can be directed through a network of distinct pathways, involving cell survival and apoptosis, cell cycling and growth, and migration and invasion, by a major regulator protein, Tiam1. A major interest is the regulation of this Tiam1/Rac signaling network in normal and malignant cells. We are also exploring the role of this network in governing interactions between tumor cells and their microenvironment.