- BA, Biology, Brandeis University
- MD, University of Vermont
- PhD, Cell, Molecular & Developmental Biology, Sackler School Tufts University
The anatomy and physiology of thyrotropin-releasing hormone (TRH) synthesizing neurons in the hypothalamic paraventricular nucleus (PVN) is the focus of our research. We study 1) the choroid plexis and cerebral spinal fluid in the transport of T4 into the brain; 2) type 2 deiodinase in ependymal cells (tanycytes) on feedback inhibition of thyroid hormone on hypophysiotropic TRH neurons in the PVN; 3) leptin-mediated paradoxic reduction in the biosynthesis of TRH in the PVN during fasting; and 4) the anatomical characterization, nuclear/cytoplasmic distribution, and potential interaction of thyroid hormone receptors in thyroid hormone responsive and unresponsive TRH neurons in the brain and their response to hormonal manipulation.