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Tufts University School of Medicine

Sergei Mirkin

White Family Professor of Biology
Programs: Genetics
Laboratory: 200 Boston Ave, Ste 4742

Sergei Mirkin

White Family Professor of Biology
Programs: Genetics
Laboratory: 200 Boston Ave, Ste 4742

Phone 617-627-4794
Lab phone: 617-627-4828
Campus: Medford

Links

Education

  • MS, Genetics, Moscow State University
  • PhD, Molecular Biology, Institute of Molecular Genetics, Moscow
  • Postdoctoral Training, Institute of Molecular Genetics, Moscow

Research synopsis

I study the mechanisms responsible for the instability of DNA repeats in various genomes. I am particularly interested in the mechanisms of expansions of triplet DNA repeats that cause numerous hereditary disorders in humans, including Fragile X mental retardation, Huntington's disease, myotonic dystrophy, and Friedreich's ataxia. My lab was the first to show that expansions could be due to the ability of these repeats to trick DNA replication into lengthening them. We are substantiating the replication model for repeat expansions in several experimental systems.