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Tufts University School of Medicine

Theoharis Theoharides

Professor of Immunology
Department: Immunology
Programs: Cell, Molecular & Developmental Biology
Laboratory: Jaharis 304

Theoharis Theoharides

Professor of Immunology
Department: Immunology
Programs: Cell, Molecular & Developmental Biology
Laboratory: Jaharis 304

Phone 617-636-6866
Lab phone: 617-636-6898
Office: Jaharis 304F
Campus: Boston

Links

Biography

Our laboratory investigates the mechanism of selective secretion of cytokines and other pro-inflammatory molecules from mast cells. We have shown for the first time that mast cells can be activated by corticotropin-releasing hormone (CRH), the first molecule generated under stress, and by interleukin-1. CRH-activated mast cells lead to disruption of the gut-blood-brain barriers and thus contribute to brain inflammation. This process may participate in the pathophysiology of many diseases that worsen or precipitate under stress.

Education

  • BA, Biology & History of Medicine, Yale University
  • MS, MPhil, Immunology, Yale University
  • PhD, Pharmacology, Yale University
  • MD, Yale University

Research synopsis

Our laboratory investigates the mechanism of selective secretion of cytokines and other pro-inflammatory molecules from mast cells. We have shown for the first time that mast cells can be activated by corticotropin-releasing hormone (CRH), the first molecule generated under stress, and by interleukin-1. CRH-activated mast cells lead to disruption of the gut-blood-brain barriers and thus contribute to brain inflammation. This process may participate in the pathophysiology of many diseases that worsen or precipitate under stress.

Publications

Conti P, Caraffa A, Ronconi G, Kritas SK, Mastrangelo F, Tettamanti L, Theoharides TC. 2017. Impact of mast cells in mucosal immunity of intestinal inflammation: Inhibitory effect of IL-37. Eur J Pharmacol. Epub ahead of print.

Conti P, Carinci F, Caraffa A, Ronconi G, Lessiani G, Theoharides TC. 2017. Link between mast cells and bacteria: Antimicrobial defense, function and regulation by cytokines. Med Hypotheses 106: 10-14.

Conti P, Carinci F, Lessiani G, Spinas E, Kritas SK, Ronconi G, Caraffa A, Theoharides TC. 2017. Potential therapeutic use of IL-37: a key suppressor of innate immunity and allergic immune responses mediated by mast cells. Immunol Res. Epub ahead of print.

Conti P, Caraffa A, Kritas SK, Ronconi G, Lessiani G, Toniato E, Theoharides TC. 2017. Mast cell, pro-inflammatory and anti-inflammatory: Jekyll and Hyde, the story continues. J Biol Regul Homeost Agents 31: 263-267.

Patel AB, Theoharides TC. 2017. Methoxyluteolin inhibits neuropeptide-stimulated proinflammatory mediator release via mTOR activation from human mast cells. J Pharmaol Exp Ther. 361: 462-471.

Theoharides TC. 2017. Vitamin D and atopy. Clin Ther. Epub ahead of print.