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Tufts University School of Medicine

William Bachovchin

Professor of Molecular & Chemical Biology
Department: Developmental Molecular and Chemical Biology
Programs: Cell, Molecular & Developmental Biology
Laboratory: M&V 607, 612, 613, ST702

William Bachovchin

Professor of Molecular & Chemical Biology
Department: Developmental Molecular and Chemical Biology
Programs: Cell, Molecular & Developmental Biology
Laboratory: M&V 607, 612, 613, ST702

Phone 617-636-6881
Lab phone: 617-636-6882
Office: M&V 613A
Campus: Boston

Links

Education

  • BS, Biology, Wake Forest University
  • PhD, Chemistry, California Institute of Technology
  • Postdoctoral Training, California Institute of Technology; Harvard Medical School

Research synopsis

The research in my laboratory includes mechanistic studies of serine proteases, and drug design and discovery. We also conduct structural studies on a variety of topics, often in collaboration with other faculty. Our serine protease studies use NMR and mutagenesis to identify and evaluate key hydrogen bonding and electrostatic interactions within serine protease active sites. The drug discovery efforts focus on the development of a platform technology for discovering new inhibitors of serine protease and the rationale design of "smarter" synthetic agents for modulating disease processes.