Skip to main content
Tufts University School of Medicine

Joshua Smalley

Postdoctoral Scholar
Department: Neuroscience

Joshua Smalley

Postdoctoral Scholar
Department: Neuroscience

Phone ​617-636-7000
Campus: Boston

Education

  • BSc, Biochemistry, University of Surrey, Surrey, United Kingdom
  • MSc, Toxicology, University of Surrey, Surrey, United Kingdom
  • PhD, Genetics, University of Leicester, Leicester, United Kingdom

Research synopsis

γ-aminobutyric acid receptors (GABAARs) are Cl- -preferring ligand-gated ion channels that mediate fast (phasic) synaptic inhibition and tonic (sustained) inhibition in the adult brain. They are important drug targets for benzodiazepines, intravenous anesthetics, and neurosteroids. My research involves the isolation and characterization of endogenous GABAAR subunit composition, studying how this can influence receptor-interacting proteins, and how this dictates the pharmacology and sub-cellular localization of GABAAR sub-types. This work involves the development of large data-rich 'omic' technologies and bioinformatic analyses with the aim of discovering novel targets for neurological diseases.