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About
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Academics
- Physician Assistant
- Special Master’s (MBS)
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Admissions & Financial Aid
- Tuition & Fees
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Student Life
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Research
- Research Labs & Centers
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Local & Global Engagement
- Global Health Program
Research/Areas of Interest:
We are interested in cell death and inflammatory responses as two critical components of the host immune defense against pathogens. We use forward genetic analysis in the wild-derived strains of mice to investigate regulatory mechanisms of cell death and inflammation. Our recent work has uncovered importance of constitutive (tonic) type I Interferon (IFN-I) in initiation of programed cell death such as pyroptosis and necroptosis. This constitutive IFN signature is induced by STING-mediated DNA-sensing pathway and maintains the expression of unknown effectors of necroptosis. We are currently focusing on identifying these effectors by means of forward genetic analysis.
Education
- Doctor of Philosophy, St. Petersburg State Technological Institute, Saint Petersburg, Russia, 1990
- Bachelor of Science, St. Petersburg University of the Humanities and Social Sciences, Saint Petersburg, Russia, 1984