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Tufts University School of Medicine

Brent Cochran

Professor of Developmental, Molecular & Chemical Biology
Department: Developmental Molecular and Chemical Biology
Programs: Genetics, Cell, Molecular & Developmental Biology, Biomedical Sciences
Laboratory: Jaharis 701B

Brent Cochran

Professor of Developmental, Molecular & Chemical Biology
Department: Developmental Molecular and Chemical Biology
Programs: Genetics, Cell, Molecular & Developmental Biology, Biomedical Sciences
Laboratory: Jaharis 701B

Phone 617-636-0442
Lab phone: 617-636-6744
Office: Jaharis 708
Campus: Boston

Links

Biography

The primary research focus of my laboratory is to understand how pathways that regulate cell growth and differentiation are disrupted in cancer. Research in my laboratory is currently focused on the study of cancer stem cells in glioblastomas. The ubiquitous growth factor and cytokine regulated Jak-Stat signal transduction pathway was discovered in my laboratory and continues to be a major focus of our research. Current projects focus on how STAT3 regulates self-renewal and differentiation in cancer stem cells and on genome-wide RNAi screens of these cells.

Education

  • SB, Biology, MIT
  • PhD, Molecular Genetics, Harvard University
  • Postdoctoral Training, Dana Farber Cancer Institute

Research synopsis

The primary research focus of my laboratory is to understand how pathways that regulate cell growth and differentiation are disrupted in cancer. Research in my laboratory is currently focused on the study of cancer stem cells in glioblastomas. The ubiquitous growth factor and cytokine regulated Jak-Stat signal transduction pathway was discovered in my laboratory and continues to be a major focus of our research. Current projects focus on how STAT3 regulates self-renewal and differentiation in cancer stem cells and on genome-wide RNAi screens of these cells.

Publications

Kulkarni S, Goel S, Sengupta S, Cochran BH. 2017. A large-scale RNAi screen identifies SGK1 as a key survival kinase for GBM stem cells. Mol Cancer Res. Epub ahead of print. [ PDF ]

Sherry-Lynes MM, Sengupta S, Kulkarni S, Cochran BH. 2017. Regulation of the JMJD3 (KDM6B) histone demethylase in glioblastoma stem cells by STAT3. PLoS One 12: e0174775. [ PDF ]

Chakraborty S, Li L, Tang H, Xie Y, Puliyappadamba VT, Raisanen J, Burma S, Boothman DA, Cochran B, Wu J, Habib AA. 2013. Cytoplasmic TRADD confers a worse prognosis in glioblastoma. Neoplasia 15: 888-897. [ PDF ]

Mihaliak AM, Gilbert CA, Li L, Daou MC, Moser RP, Reeves A, Cochran BH, Ross AH. 2010. Clinically relevant doses of chemotherapy agents reversibly block formation of glioblastoma neurospheres. Cancer Lett. 296: 168-177. [ PDF ]

Carette JE, Guimaraes CP, Varadarajan M, Park AS, Wuethrich I, Godarova A, Kotecki M, Cochran BH, Spooner E, Ploegh HL, Brummelkamp TR. 2009. Haploid genetic screens in human cells identify host factors used by pathogens. Science 326: 1231-1235. [ PDF ]

Sherry MM, Reeves A, Wu JK, Cochran BH. 2009. STAT3 is required for proliferation and maintenance of multipotency in glioblastoma stem cells. Stem Cells 27: 2383-2392. [ PDF ]