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Tufts University School of Medicine

Alexander Poltorak

Associate Professor of Immunology
Department: Immunology
Programs: Genetics, Immunology, Molecular Microbiology
Laboratory: Jaharis 527

Alexander Poltorak

Associate Professor of Immunology
Department: Immunology
Programs: Genetics, Immunology, Molecular Microbiology
Laboratory: Jaharis 527

Phone 617-636-3596
Lab phone: 617-636-3945
Office: Jaharis 529A
Campus: Boston

Links

Education

  • BS, Chemistry, St Petersburg University
  • PhD, Chemistry, Technological Institute
  • Postdoctoral Training, University of Texas Southwestern Medical Center

Research synopsis

We are interested in cell death and inflammatory responses as two critical components of the host immune defense against pathogens. We use forward genetic analysis in the wild-derived strains of mice to investigate regulatory mechanisms of cell death and inflammation. Our recent work has uncovered importance of constitutive (tonic) type I Interferon (IFN-I) in initiation of programed cell death such as pyroptosis and necroptosis. This constitutive IFN signature is induced by STING-mediated DNA-sensing pathway and maintains the expression of unknown effectors of necroptosis. We are currently focusing on identifying these effectors by means of forward genetic analysis.