- BA, Art History & Neuroscience, University of Pittsburgh
- BS, Art History & Neuroscience, University of Pittsburgh
- PhD, Neuroscience, George Washington University
- Postdoctoral Training, University of California, Los Angeles
Research in the Maguire lab investigates the contribution of stress and GABAergic inhibition to the underlying neurobiology of neurological and neuropsychiatric disorders, including epilepsy, postpartum depression, major depression, anxiety disorders, and alcohol/substance use disorders. The Maguire lab has a particular focus on extrasynaptic GABAA receptors (GABAARs) which are sensitive to neurosteroids and the role of these receptors in regulating stress-related circuits. Given the adverse effects of stress on numerous health outcomes, the Maguire lab’s research is able to span multiple research areas, investigating novel mechanisms whereby stress contributes to the underlying neurobiology of disease and identifying potential targets for treatment. Her work has led to the first treatment specifically for postpartum depression, which is currently awaiting FDA approval. Research in the Maguire lab has received significant media attention and sparked collaborations both within and outside of Tufts, has been supported by several foundation grants, including a Young Investigator Award from the American Epilepsy Society; four substantial R01 Research Project Grants from the National Institutes of Health; and a sponsored research agreement with Sage Therapeutics. .