Li Zeng

Li Zeng

(617) 636-2107
150 Harrison Ave
Research/Areas of Interest: My lab studies cartilage development and cartilage-related diseases using interdisciplinary approaches. Abnormality in cartilage development leads to defects in skeletogenesis. In adults, destruction of the articular cartilage on the surface of the bone is the hallmark of arthritis, which is marked by joint inflammation and pain. A major focus is to investigate molecular and cellular changes in the initiation and progression of osteoarthritis. By interrogating the metabolic control of developmental phases in cartilage growth, we gain important insights into bone and joint regeneration for the treatment of skeletal defects and osteoarthritis.


  • Doctor of Philosophy, Columbia University, New York, United States
  • Masters of Philosophy, Columbia University, New York, United States
  • Masters of Science, Tsinghua University, Beijing, China
  • Bachelor of Science, China Agricultural University, Haidian, China


Osteoarthritis is a widespread chronic disease characterized by joint pain and immobility. What happens to our joints in osteoarthritis? What can we do to treat it? Our research group strives to address these questions using animal models and human tissue culture systems. By investigating the mechanisms of cartilage and bone growth, we aim to provide new strategies to regenerate damaged joints to treat osteoarthritis. To meet these challenges with novel angles, we have formed exciting collaborations with experts from the fields of engineering, orthopedics, rheumatology, and pharmacology. Joined us in this endeavor are trainees of all levels. Through a strong commitment to mentoring, we promote excellence in scientific research and education.