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Tufts University School of Medicine

Claire Moore

Natalie V. Zucker Professor of Developmental, Molecular & Chemical Biology
Department: Developmental Molecular and Chemical Biology
Programs: Cell, Molecular & Developmental Biology, Genetics, Molecular Microbiology
Laboratory: Jaharis 401A

Claire Moore

Natalie V. Zucker Professor of Developmental, Molecular & Chemical Biology
Department: Developmental Molecular and Chemical Biology
Programs: Cell, Molecular & Developmental Biology, Genetics, Molecular Microbiology
Laboratory: Jaharis 401A

Phone 617-636-6935
Lab phone: 617-636-3645
Office: Jaharis 408
Campus: Boston

Links

Education

  • BS, Chemistry, MIT
  • MSc, Neuroscience, MIT
  • PhD, Microbiology, University of North Carolina, Chapel Hill
  • Postdoctoral Training, Pasteur Institute; MIT

Research synopsis

My research group studies maturation of eukaryotic mRNA through an essential and conserved process called polyadenylation. Functional mRNAs are not made without this processing step, and cells also use it to regulate gene expression during development, differentiation, or in response to external signals. Our goal is to determine the molecular mechanisms of mRNA polyadenylation, its regulation in response to changes in cell status, and its coordination with other nuclear processes such as transcription and DNA damage repair. We use biochemistry, molecular biology, genetics and whole-genome expression analysis to study these issues. Most eukaryotic genes have multiple poly(A) sites, and choice of poly(A) site can have profound effects on the type and amount of protein made from a particular gene. We are particularly interested in understanding mechanisms that lead to such alternative polyadenylation, both in normal cells and in disease states such as cancer or chronic stress.