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Tufts University School of Medicine

Ralph Isberg

Professor of Molecular Biology & Microbiology
Department: Molecular Biology and Microbiology
Programs: Genetics, Molecular Microbiology
Laboratory: Jaharis 424A

Ralph Isberg

Professor of Molecular Biology & Microbiology
Department: Molecular Biology and Microbiology
Programs: Genetics, Molecular Microbiology
Laboratory: Jaharis 424A

Phone 617-636-3993
Lab phone: 617-636-4092
Office: Jaharis 423
Campus: Boston

Links

Education

  • AB, Chemistry, Oberlin College
  • PhD, Microbiology, Harvard University
  • Postdoctoral Training, Stanford University

Research synopsis

Our research is directed toward answering three questions concerning the lifestyle of invasive bacterial pathogens: How are intracellular pathogens able to penetrate into normally nonphagocytic epithelial cells? What factors do intracellular bacteria encode that allow them to survive and grow within the normally hostile environment of macrophages? What role do factors that are important for bacterial-host cell interaction models play in an infection of the host? We perform genetic and biochemical experiments on two bacterial pathogens, the bacterium Yersinia pseudotuberculosis, and Legionella pneumophila, the causative agent of Legionnaire's disease pneumonia.