Research/Areas of Interest:
Our research work has a focus on the following areas: molecular and clinical pharmacokinetics/pharmacodynamics; genetic and environmental factors regulating drug metabolism by Cytochromes P450 and glucuronosyl transferases, and energy-dependent transport by P-glycoprotein and other transporters; mechanisms, consequences, and in vitro prediction of metabolic drug-drug interactions attributable to enzyme inhibition and induction; effect of age, gender, body habitus, and dietary composition on drug disposition and response; drug interactions involving nutrients and natural substances; molecular and clinical determinants of ligand binding and pharmacodynamic response to centrally-acting drugs. Principal techniques used in the laboratory include: high-pressure liquid chromatography (HPLC) and HPLC with mass spectroscopy for quantitation of drugs and metabolites; in vitro drug metabolism models based on human liver microsomal preparations and recombinant human enzymes; genetic identification and quantitation of single nucleotide polymorphisms altering drug metabolism phenotype; nonlinear regression procedures for pharmacokinetic/pharmacodynamics simulation and modeling.
Doctor of Medicine, Harvard Medical School, USA, 1970
Bachelor of Arts, Amherst College, USA, 1966
Louis Lasagna Endowed Professor, Department of Immunology (formerly the Department of Pharmacology and Experimental Therapeutics); Professor of Psychiatry, Medicine, and Anesthesia, Tufts University School of Medicine; Special and Scientific Staff (Research), Tufts Medical Center, Boston MA
h-index (Google Scholar): 121
Critical Collaborators (not presently at Tufts): Lisa L. von Moltke -- 172 Hermann R. Ochs -- 111 Darrell R. Abernethy -- 105 Michael H. Court -- 57