Linden Hu

Linden Hu

55 Kneeland Street
Research/Areas of Interest:

The focus of my research is on Lyme disease. My laboratory is interested in the pathogenesis of Lyme disease both from the perspective of how the bacteria adapt to its different host environments as well as how the host immune response recognizes the organism and is responsible for the pathology associated with the infection. As a physician scientist, my overall goals are to be able to improve prevention, treatment and diagnosis of human Lyme disease and to this end, we have been working on projects to develop vaccines and improved diagnostics for the presence of disease after antibiotic therapy.


  • Doctor of Medicine, Brown University, USA, 1990
  • Artium Baccalaureatus, Brown University, USA, 1987


Dr. Linden Hu is the Paul and Elaine Chervinsky Professor of Immunology at Tufts Medical School. Dr. Hu received his A.B. and M.D. from Brown University. He completed training in Infectious Diseases at Tufts Medical Center. His laboratory works on multiple aspects of Lyme disease including vaccine development, new diagnostics and treatments, and understanding interactions between Borrelia burgdorferi and its tick and animal hosts. Most recently, his lab has been researching how the organism evades the host immune response and how human genetic mutations may alter the ability of the bacterial host to control inflammatory responses. The lab is also partnering with other laboratories on strategies to eradicate tick borne pathogens from their wild reservoirs.