Signe's research focuses on the U.S. health care system, state and federal health policy, aging, and serious illness. Through her research, Signe aims to improve the effectiveness of the health care system through organization, system, and policy-level interventions. She conducts mixed methods evaluations of care delivery interventions implemented in a variety of settings, including primary care practices, hospitals, cancer centers, community-based palliative care providers, and aging services organizations. In particular, Signe's research focuses on identifying strategies to improve outcomes among older adults living with serious and complex chronic illness together with their caregivers. Signe is the Co-Director of the Center for Health Systems and Policy at Tufts University School of Medicine. Prior to her career in academia, Signe served as a Presidential Management Fellow at the Centers for Medicare and Medicaid Services in the Medicaid Division, and as a policy analyst for non-profit organizations examining the impact of health policy on low-income populations and people with disabilities.