Biochemistry Takes Center Stage in Research Spotlight

Christina McGuire and Mike Forgac focus on the role of V-ATPase in signaling during nutrient starvation.
Presentation Slide showing glucose starvation increases V-ATPase assembly and activity in mammalian cells through AMP kinase and phosphatidylinositide 3-kinase/Akt signaling
drawing: Katie Lew

Christina McGuire, a fifth year PhD student in the Biochemistry Program and her advisor, Michael Forgac, PhD have been studying signaling involving V-ATPase and its role in autophagy and glucose starvation.

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Some of her recent work is described in the following publication:

McGuire CM, Forgac M. 2018. Glucose starvation increases V-ATPase assembly and activity in mammalian cells through AMP kinase and phosphatidylinositide 3-kinase/Akt signaling. J Biol. Chem. Epub ahead of print.  Abstract